Functional diversity among spectrin isoforms

Functional Differences Among Multiple Isoforms

Spectrin isoforms in the mammalian retina.

Spectrin is a major component of the mammalian neuronal cytoskeleton. In the CNS, three isoforms of brain spectrin are known to exist: a cellular and dendritic isoform, (240/235E), related to neurons and glia; a cellular and axonal isoform, (240/235), related to neurons; and an isoform specific for astrocytes, (240/235A). In the present study, brain spectrins (240/235E) and (240/235) were local...

Structural and functional diversity of novel coronin-1C (CRN2) isoforms

Center for Biochemistry, Institute of Biochemistry I, Medical Faculty, Center for Molecular Medicine, and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Germany Department of Neurology, University Hospital Bonn, Germany Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Ludwig Maximilians-Universität, Germany...

Isoforms of Spectrin and Ankyrin Reflect the Functional Topography of the Mouse Kidney

The kidney displays specialized regions devoted to filtration, selective reabsorption, and electrolyte and metabolite trafficking. The polarized membrane pumps, channels, and transporters responsible for these functions have been exhaustively studied. Less examined are the contributions of spectrin and its adapter ankyrin to this exquisite functional topography, despite their established contri...

Drosophila Ecdysone Receptor Mutations Reveal Functional Differences among Receptor Isoforms

The steroid hormone ecdysone directs Drosophila metamorphosis via three heterodimeric receptors that differ according to which of three ecdysone receptor isoforms encoded by the EcR gene (EcR-A, EcR-B1, or EcR-B2) is activated by the orphan nuclear receptor USP. We have identified and molecularly mapped two classes of EcR mutations: those specific to EcR-B1 that uncouple metamorphosis, and embr...